Endocrine Abstracts

Objective: Evaluate the efficacy and safety of adding lixisenatide to uncontrolled type 2 diabetic (T2DM) patients treated with insulin.Methods: A prospective uncontrolled study was designed. Primary endpoints (measured at 3 and 6 months) were change in HbA1c, weight, and insulin doses. Variables analysed were: HbA1c level, insulin and other hypoglycaemic agents doses, capillary glucose tests, number and type of hypoglycaemias, side effects and body comp...

Introduction: Gestational diabetes mellitus (GDM) is associated with an increase risk of neonatal and maternal complications. Continuous glucose monitoring (CGM) detects glycemic patterns, which could help predict the development of maternal-fetal complications.Objective: To analyze the different glycemic patterns obtained with CGM and to correlate them with the appearance of maternal-fetal complications in GDM.Methods: Women with ...

Background: Recent studies have shown that the incidence of differentiated thyroid cancer (DTC) is increasing.Objective: Evaluate the incidence of DCT in a center of the south of Spain for the last 15 years and analyse the clinical and morphological factors related to DTC.Methods: We reviewed the series of patients undergoing thyroid surgery at our hospital over a 15-year period and identified patients with DTC. Patients were divid...

Introduction: Ghrelin is a gastrointestinal peptide involved in the regulation of body weight and energy balance. However, its behavior after bariatric surgery and its relationship with other biochemical variables is still under discussion. We aim to undertake a simultaneous evaluation of the changes in ghrelin levels after three types of bariatric surgery and its relationship with different variables.Design: The study included 21 non-obese and 103 morbi...

Objective: The aim of this study was to examine the impact of a web-based telemedicine system for monitoring glucose control in pregnant women with diabetes on health care visits, metabolic control and pregnancy outcomes.Subjects and methods: A prospective, single-centre, and interventional study with two parallel groups was performed in Puerto Real University Hospital (Spain). Women were assigned to two different glucose monitoring groups: control group...

Background: Heart failure (HF) is a chronic inflammatory syndrome, with increased morbidity, mortality, and decreased quality of life. The publication of GLIM criteria has standardized the diagnosis of malnutrition. With these criteria, the nutritional status of patients with heart failure, who usually have normal weight, overweight or obesity, has acquired a new perspective, since malnutrition may affect the clinical evolution and prognosis of these patients.<p class="abs...

Introduction: Obesity is associated with an increasing risk of diabetes and atherosclerosis. Previous studies in animals show that oxidized low-density lipoprotein (Ox-LDL) can be captured by the adipocyte through different scavenger receptors (SR) and thus contribute to the worsening of insulin resistance (IR). We analyze the association between Ox-LDL levels and different SR present in adipose tissue and their relationship with the presence of obesity and insulin resistance ...

Introduction: HIF-1α, a hypoxia marker, is an important factor for transcriptional regulation of cell metabolism and the adaptation to cellular stress. It modulates the function of phagocytic cells by stimulating surface receptors such as scavenger receptors. But little is known on their relationship in adipose tissue, whose increase has been associated with an increased risk of atherosclerosis. The aim of this study is to analyze in adipose tissue the association between...

Introduction: In recent years, numerous studies on the relationship between the TSH of the first trimester of pregnancy and obstetric complications have been published, and in this context it has been recommended to treat with levothyroxine from certain values of TSH. The aim of this study was to determine the incidence of obstetric and neonatal complications in pregnancies with normal TSH (0.14 to 2.49 mcU/ml) as a basis for assessing complications in pregnancies with TSH bet...

Objectives: To study vitamin D deficiency in a cohort of obese males and to evaluate associated clinical and biochemical characteristics.Methods: Case-control study which included obese (defined by a BMI ≥30 kg/m2) males. Vitamin D deficiency was defined as vitamin D levels <20 ng/ml. Estimation of vitamin D status was determined in serum using a commercially available enzyme- immuno-assay designed to measure 25-OH Vitamin D concentr...